Uk pubmed central (ukpmc) requires javascript to function effectively. Either your web browser doesn't support javascript or it is currently turned off. In the latter case, please turn on javascript support in your web browser and reload this page. viagra pills   feedback ukpmc labs >> home about funders governance contact us europe pubmed central rss feeds journal list grant lookup faq and guides guides ukpmc+ clear search advanced search recent activity  |  clipboard instability of cag repeats in huntington's disease: relation to parental transmission and age of onset. (pmid:8064815) abstract citations bioentities related articles find all citations by this author (default). Or filter your current search trottier y , find all citations by this author (default). Or filter your current search biancalana v , find all citations by this author (default). Or filter your current search mandel jl lgme/cnrs, facultã© de mã©decine, centre hospitalier regional universitaire, strasbourg, france. viagra canada Find all citations in this journal (default). Or filter your current search journal of medical genetics [1994, 31(5):377-382] type:  journal article, research support, non-u. can take viagra viagra same time S. Gov't abstract highlight terms gene ontology(1) diseases(6) genes/proteins(1) huntington's disease ( hd ) has recently been found to be caused by expansion of a trinucleotide ( cag ) repeat within the putative coding region of a gene with an unknown function. We report here an analysis of hd mutation and the characteristics of its transmission in 36 hd families. viagra for women herbally Cag repeats on hd chromosomes were unstable when transmitted from parent to offspring. cost for viagra 100mg Instability appeared more frequent and stronger upon transmission from a male than from a female, with a clear tendency towards increased size. We have also found a significant inverse correlation (p = 0. buy viagra online 0001) between the age of onset and the cag repeat length. The observed scatter would, however, not allow an accurate individual prediction of age of onset. Three juvenile onset cases analysed had an hd mutation of paternal origin. online viagra without prescription In at least two of these cases a large expansion of the hd allele upon paternal transmission may explain the major anticipation observed. Our results suggest that several features of the expansion mutation in hd are similar to those previously observed for mutations of similar size in spinobulbar muscular atrophy and in myotonic dystrophy , and to those observed more recently in spinocerebellar ataxia type 1 and in dentatorubropallidoluysian atrophy , four diseases also c. viagra samples order viagra